Carsten Prasse, Assistant Professor
My research is driven by a fascination with environmental chemistry and a deep concern about the public and environmental health impacts of chemicals present in our environment. My research group investigates the fate of contaminants in the built and natural environment using state-of-the-art analytical chemistry techniques (e.g. high-resolution mass spectrometry) with the focus on identifying transformation products and understanding underlying mechanisms of transformation. One of our main areas of interest is the presence of contaminants in the urban water cycle. Even though the efficacy of treatment technologies is still primarily evaluated based on the removal of well-known trace organic contaminants, our research has emphasized the relevance of transformation products as (drinking) water contaminants.
The recognition of the relevance of transformation products as emerging class of water contaminants led to a series of studies in which we investigated the fate of transformation products in treatment trains used in both wastewater treatment and drinking water purification. This was paired with in vitro and in silico toxicological approaches to assess the toxicity of the transformation products. The results have clearly demonstrated that degradation processes can result in transformation products that exhibit an increased toxicity compared to the parent chemicals. This is particularly relevant for the assessment of new treatment technologies as well as alternative drinking water resources, in particular regarding water reuse.
One widely unanswered question is how to prioritize the compounds that are present and how to identify which compounds are most threatening to human and environmental health given that thousands of chemicals are present in our waters. To tackle this problem, our research focuses on using concepts and methods from toxicology and public health. This work is interdisciplinary with the goal of developing new methodologies to inform water treatment technology development, comprehensively assess water quality and characterize the Exposome.
Full list of publications: Google Scholar Citations
Matthew Newmeyer, Postdoc
I have always been driven to contribute to the betterment of society through the use and advancement of science. We are at a critical juncture where increased attention and action regarding environmental issues are paramount. My goal is to use my interests in analytical chemistry and toxicology to help better understand these problems and lead to actionable solutions. Through the use of targeted and non-targeted analytical detection methods, we can help characterize the compounds we come in contact with on a daily basis through the water we drink, food we eat and air we breathe. Coupling these finding with toxicological testing can improve risk assessments and improve human health outcomes. Additionally, these data can assist with various environmental issues from improving water treatment practices to assessing air quality, and may ultimately help inform evidence-based public health policies. I am fascinated in this interplay of analytical chemistry, toxicology, public health and policy.
Veronica Wallace, PhD student
Environmental Health and Engineering forges interdisciplinary problem-solving approaches across many otherwise disparate disciplines. As a PhD student, I aim to undertake training and research at the confluence of public health, environmentalism, and engineering, targeting issues of immediate concern in our local community and global environment. My research interests are shaped by the environmental and health disparities I have witnessed living in the city of Baltimore, and also by my long-standing interests in medicine and individual health. After completing my BA in Anthropology at Yale University, I received my Master’s of Science in Bioengineering from the University of Pennsylvania. I made my foray into Public Health interning at the World Health Organization in Geneva, Switzerland, with the unique opportunity to bring experience in biomedical engineering to work in the Department of HIV/AIDS Key Populations and Innovation Prevention Team. My post-grad work has since spanned clinical and biomedical research. I moved to Baltimore, MD to work with Dr. Bruce Hope at the NIH National Institute on Drug Abuse, and continued to develop my interests in environmental and public health living and working in Baltimore. Prior to starting my PhD in summer 2018, I worked with a biotech startup in Baltimore. Returning to academia and embarking on my doctoral degree, innovation and interdisciplinary problem-solving are at the forefront of my research endeavors.
Chris Brueck, PhD student
I developed a strong passion for environmental engineering and science in college after working with a research team to help remediate the ecological devastation caused by the Valdez and Deepwater Horizon oil spills. Since then I have spent my efforts studying the fate of contaminants in natural and engineered environments using both experimental- and modeling-based approaches. After receiving my MS in Environmental Engineering (2016) from Oregon State University on the topic of colloid transport in the vadose zone, I returned to my hometown of Baltimore to start a PhD program at Johns Hopkins University.
My current research focuses on the impact of organic contaminants on wastewater treatment and bioenergy production in anaerobic digesters. As a co-advised student in both the Prasse and Bouwer labs (EHE), I hope to bridge environmental chemistry and microbiology using state-of-the-art analytical and molecular tools so that we may better relate chemical transformations, microbial inhibition, and overall reactor “process upsets.” To this end, we employ high-resolution mass spectrometry for metabolomics and non-targeted chemical analysis to realize connections between pharmaceuticals (human and veterinary) and microbial metabolism occurring in anaerobic digesters. With this information we will propose improvements to the wastewater treatment paradigm in municipal and agricultural settings and assess options for sludge and digestate recycling.
Outside of the lab you will find me playing local gigs as the guitarist in my band or eating too much food at one of the many awesome restaurants around Baltimore!
Zhuoyue Zhang, PhD student
As the generation born after 1995, I witnessed the rapid deterioration of river systems in my hometown, Xiangyang, which is a miniature scenario of ecosystem status in China under the big background of high-speed economic development. Since my first research project as an undergraduate student on utilization of Advanced Oxidation Processes with assistance of homemade catalysts to degrade dyes in aqueous system, I’ve been intentionally focusing my research interest on water resource and treatment issues. Since majoring in environmental engineering I have never been more compelled about my responsibility since majoring in environmental engineering majored student after the 12 weeks research internship program in University of Saskatchewan, Canada. It is not because of how interesting my first research experience abroad was, but simply of a camping trip to a small lake there. The purity, the transparency and the beauty of the lake water touched my heart so profoundly that it inspired me to continue my study and research on environmental issue. All of these journeys added up to lead me here to work in the Prasse lab. I really enjoy the interesting research topics and open atmosphere in the lab and strongly believe this research experience will be one of the most unforgettable memories in my whole life.
Daisy Grace, PhD student
Growing up in a rural town outside of Reading, Pennsylvania, I witnessed how agricultural- and septic-based runoff sparked an increasing frequency of health advisories at a nearby recreational lake due to fecal bacteria and algal bloom contamination. Observing the quality decline of the place where I spent my childhood summers motivated my intellectual curiosity regarding environmental contamination, particularly as a consequence of increased anthropogenic activity.
I decided to pursue my interest in environmental issues at Lafayette College, where I joined Dr. Melissa Galloway’s atmospheric aerosol lab in the Department of Chemistry. In the Galloway Lab, I investigated brown carbon aerosol systems and their radiative properties to help inform global climate modeling. This work familiarized me with mass spectrometry (MS) method development, which served to identify individual products within complex environmental matrices. Seeing how powerful MS was in identifying environmental contaminants, I knew I wanted to continue working with MS in my graduate career. My work with atmospheric aerosols, however, confirmed my inclination toward more solution-oriented approaches in research regarding the fate and transport of aqueous contaminants. This revelation has led to my current position as a PhD candidate in the Prasse Lab, where I can continue to explore my fascination in environmental analytical chemistry while also acquiring a background in engineering and public health. My current project involves designing a novel analytical platform to detect, identify, and prioritize individual toxic contaminants within complex drinking water and wastewater samples. Alongside this project, I am looking forward to participating in the collaborative nature of the Prasse Lab with both the academic and Baltimore communities.
In my free time, I enjoy hiking, swimming, making recycled art, and working through a long list of recommended podcasts.
Casey Smith, PhD student
My interests in environmental materials stem from a passion for solving puzzles and a desire to tackle real-world problems with analytical chemistry. While pursuing BS degrees in Chemistry and Biochemistry at Virginia Tech, I had the opportunity to work at a materials analysis lab in Christiansburg, VA. During this time, I learned about the types of polymers that comprise our every-day products, the additives incorporated into plastics to enhance their properties, and the techniques capable of detecting and characterizing these chemicals. While at JHU, I have continued to pursue my interest in analyzing plastic additives, as well as their implications on the environment and public health.
My current research focuses on the release and transformations of polymer additives in aqueous environments. Despite the ever-growing use and disposal of plastics, the factors governing the rate of additive release and the mechanisms and end products of potential transformation remain undetermined. As a co-advised Ph.D. student in both the Prasse and Fairbrother labs (JHU Department of Chemistry), I hope to bridge the gap between materials design and consideration of future health risks.
The diverse background and collaborative nature of the Prasse Lab makes every day insightful and interesting! When not in lab, I enjoy reading, baseball, watching Jeopardy, and spending time with my family.
Xiaoyue Xin, Master’s student
My research interest is driven by my concern about water pollution issues in China and my long-standing interest in environmental chemistry. After nearly half a year of internship in SAES, a Research Institute in Shanghai during my undergraduate, I deeply realized the seriousness of the water quality problem in my country, and how proper treatment of wastewater and drinking water purification is directly related to our surrounding environment and our own health. It also strengthened my determination to continue my research in this field. After completing my BA at ECUST, China and at THL, Germany, I started my MS in the Department of Environmental Health and Engineering at Johns Hopkins University with focus environmental process engineering. In the Prasse lab, I am particularly interested in research about the impacts of organic contaminants on wastewater treatment processes and bioenergy production in anaerobic digesters. Outside the lab, you will probably find me taking photos on campus and painting pictures in my apartment.
Melody Multra, Undergraduate student
I am a Chemical and Biomolecular Engineering major at Hopkins with a minor in environmental studies. Growing up in Taiwan, the prevalence of pollution has always been a very apparent issue to me, and once moving to Illinois my interest in pollution in water and wastewater treatment grew through explorative summer programs at UIUC. Since coming to college, I have discovered and developed a passion for the intersection of environmental chemistry and public health, and the more I’ve learned about the wide-range of contaminants and the harm they pose to human and environmental health the more motivated I am to continue pursuing these answers. Currently, I am focusing on research of the degradation of agricultural pharmaceuticals in anaerobic digestion processes. Outside of classes, you would likely find me running and listening to music or singing in choir at peabody!
Annabel Mungan, Undergraduate student
Growing up in Annapolis, Maryland, I spent much of my childhood kayaking, crabbing, and swimming in my creek on the Chesapeake Bay. As I was visibly aware of the pollution the Bay suffers from, I developed an interest in water quality issues. I am now studying Environmental Engineering at Hopkins and am interested in research related to water treatment and quality. Even in our drinking water, there are many human-induced contaminants that we don’t know a lot about, and I am interested in using analytical chemistry and engineering techniques to detect and remove these compounds. Outside of my academics, you’ll probably find me training with the triathlon club, listening to folk music, or taking nine-minute-long naps around campus!
Nick Pham, High School student
Growing up on the both coasts of the U.S. exposed me to the diverse amount of life supported by the water in the oceans. Later, I learned the importance of clean water when I did an engineering project in middle school about runoff leading to dead zones in the nearby Chesapeake Bay. Now, I have been given the opportunity by my high school, the Baltimore Polytechnic Institute, to pursue a two-year research experience in partnership with a local university. I chose to continue learning about the importance of water purification and sanitation, and the Prasse Lab was generous enough to provide this opportunity to me. At the Prasse Lab, I am mentored by PhD student Zhuoyue Zhang, and I learn about the relevance of disinfection byproducts in water as a result of chlorination. I am continuing to explore the formation and effects of certain byproducts and comparing different oxidative methods that are used for water purification globally. I hope eventually I can share the significance of my research with my peers at school and the locals in my community.
Previous lab member:
- Sara Nason (Postdoc): current position: research scientist at the Connecticut Agricultural Research Station
- Ximin Hu (Master’s student): current position: PhD student University of Washington, Department of Civil & Environmental Engineering
- Rafael Ferguson (undergraduate Student): current position: Master’s student Johns Hopkins University, Environmental Health & Engineering
- Marcos Pascual (undergraduate student): current position: Master’s student Johns Hopkins University, Environmental Health & Engineering