Carsten Prasse, Assistant Professor
My research is driven by a fascination with environmental chemistry and a deep concern about the public and environmental health impacts of chemicals present in our environment. My research group investigates the fate of contaminants in the built and natural environment using state-of-the-art analytical chemistry techniques (e.g. high-resolution mass spectrometry) with the focus on identifying transformation products and understanding underlying mechanisms of transformation. One of our main areas of interest is presence of contaminants in the urban water cycle. Even though the efficacy of treatment technologies is still primarily evaluated based on the removal of well-known trace organic contaminants, our research has clearly demonstrated the relevance of transformation products with some of them even being present in our drinking water.
The recognition of the relevance of transformation products as emerging class of water contaminants led to a series of studies in which we investigated the fate of transformation products in treatment trains used in both wastewater treatment and drinking water purification. This was paired with in vitro and in silico toxicological approaches to assess the toxicity of the transformation products. The results have clearly demonstrated that degradation processes can result in transformation products that exhibit an increased toxicity compared to the parent chemicals. This is particularly relevant for the assessment of new treatment technologies as well as alternative drinking water resources, in particular regarding water reuse.
One widely unanswered question is how to prioritize the compounds that are present and how to identify which compounds are most threatening to human and environmental health given that thousands of chemicals are present in our waters. To tackle this problem, our research focuses on using concepts and methods from toxicology and public health. This work is interdisciplinary with the goal of developing new methodologies to inform water treatment technology development, comprehensively assess water quality and characterize the Drinking Water Exposome.
Full list of publications: Google Scholar Citations
Ping He, Postdoc
My research interests include the development of methods to identify chemicals and their effects to biological and environmental systems. After I graduated in 2018 with a PhD in Analytical Chemistry from the University of Buffalo, I joined the Prasse lab to focus on environmental/public health research. My previous experiences cover the development of mass spectrometry based methods (LC-MS/MS, GC-MS/MS, and LC-ICP-MS) and sample preparation strategies (functionalized nanodiamond sorbents) for the analysis of pesticides, hormones, metals, and biomarkers of endocrine disruption in the environment. I am fascinated by the application of new analytical techniques to study increasingly complex chemical mixtures that are present in the environment and how these tools can be used to develop new research directions. High-resolution mass spectrometry is particularly important as it open the door to investigate the unknowns beyond traditional targeted analysis. I would love to work with the group to explore how the new methodologies address the blind spots of environmental/public health research.
Veronica Wallace, PhD student
Environmental Health and Engineering forges interdisciplinary problem-solving approaches across many otherwise disparate disciplines. As a PhD student, I aim to undertake training and research at the confluence of public health, environmentalism, and engineering, targeting issues of immediate concern in our local community and global environment. My research interests are shaped by the environmental and health disparities I have witnessed living in the city of Baltimore, and also by my long-standing interests in medicine and individual health. After completing my BA in Anthropology at Yale University, I received my Master’s of Science in Bioengineering from the University of Pennsylvania. I made my foray into Public Health interning at the World Health Organization in Geneva, Switzerland, with the unique opportunity to bring experience in biomedical engineering to work in the Department of HIV/AIDS Key Populations and Innovation Prevention Team. My post-grad work has since spanned clinical and biomedical research. I moved to Baltimore, MD to work with Dr. Bruce Hope at the NIH National Institute on Drug Abuse, and continued to develop my interests in environmental and public health living and working in Baltimore. Prior to starting my PhD in summer 2018, I worked with a biotech startup in Baltimore. Returning to academia and embarking on my doctoral degree, innovation and interdisciplinary problem-solving are at the forefront of my research endeavors.
Chris Brueck, PhD student
I developed a strong passion for environmental engineering and science in college after working with a research team to help remediate the ecological devastation caused by the Valdez and Deepwater Horizon oil spills. Since then I have spent my efforts studying the fate of contaminants in natural and engineered environments using both experimental- and modeling-based approaches. After receiving my MS in Environmental Engineering (2016) from Oregon State University on the topic of colloid transport in the vadose zone, I returned to my hometown of Baltimore to start a PhD program at Johns Hopkins University.
My current research focuses on the impact of organic contaminants on wastewater treatment and bioenergy production in anaerobic digesters. As a co-advised student in both the Prasse and Bouwer labs (EHE), I hope to bridge environmental chemistry and microbiology using state-of-the-art analytical and molecular tools so that we may better relate chemical transformations, microbial inhibition, and overall reactor “process upsets.” To this end, we employ high-resolution mass spectrometry for metabolomics and non-targeted chemical analysis to realize connections between pharmaceuticals (human and veterinary) and microbial metabolism occurring in anaerobic digesters. With this information we will propose improvements to the wastewater treatment paradigm in municipal and agricultural settings and assess options for sludge and digestate recycling.
Outside of the lab you will find me playing local gigs as the guitarist in my band or eating too much food at one of the many awesome restaurants around Baltimore!
Andres Lam, Senior Research Specialist
After receiving my MSc degree in Pharmaceutical Sciences from Campbell University (NC), I arrived at the Johns Hopkings School of Public Health as a Research Specialist. My recent work is related to the field of Analytical Chemistry, specifically GC-MS analysis and method development that includes solid-phase microextraction (SPME), used to key volatile organic compounds (VOCs), which offers quality assurance for a device that could screen for lung cancer from exhaled breath. My other projects include the analysis of nicotine and its derivatives on a study about second-hand smoking, water-pipes, and e-cigarettes. Before working with the Environmental Health Engineering department, I worked with the Human Nutrition Department, where I used HPLC, AA spectroscopy, and ELISA techniques to study minerals and micronutrients such as VitaminA (via retinol and RA), zinc, iron (via ferritin and TfR), iodine, and alpha-1-acid glycoprotein (AGP) on serum, blood and urine samples.
My goal is to use my laboratory skills as a main tool to conduct high-quality research in the fields of pharmaceuticals and analytical chemistry, in support on improving public health and health-care community. I have special interest in learning and developing new methodologies in the field of proteomics, which would help me expand my knowledge about structures and functions of proteins, and further increase my skills in mass spectrometry and protein profiling. I’m originally from Ecuador. Outside of work, I like playing soccer, video games, hiking, and photography.
Zhuoyue Zhang, Master’s student
As the generation born after 1995, I witnessed the rapid deterioration of river systems in my hometown, Xiangyang, which is a miniature scenario of ecosystem status in China under the big background of high-speed economic development. Since my first research project as an undergraduate student on utilization of Advanced Oxidation Processes with assistance of homemade catalysts to degrade dyes in aqueous system, I’ve been intentionally focusing my research interest on water resource and treatment issues. Since majoring in environmental engineering I have never been more compelled about my responsibility since majoring in environmental engineering majored student after the 12 weeks research internship program in University of Saskatchewan, Canada. It is not because of how interesting my first research experience abroad was, but simply of a camping trip to a small lake there. The purity, the transparency and the beauty of the lake water touched my heart so profoundly that it inspired me to continue my study and research on environmental issue. All of these journeys added up to lead me here to work in the Prasse lab. I really enjoy the interesting research topics and open atmosphere in the lab and strongly believe this research experience will be one of the most unforgettable memories in my whole life.
Ximin Hu, Master’s student
I believe that engineering is the foundation on which humankind shapes the Earth into a better and more sustainable place to live. I always had a strong curiosity to learn science and its applications, which naturally lead me to environmental engineering. My interest in Environmental Engineering deepened during my undergraduate research, which we focused on a natural water treatment system by collecting data from the Qingcaosha reservoir, Shanghai. Since then, I realized the relationship between the water treatment system and our daily life. In the Prasse Lab, my research interests are mostly related to drinking water treatment and disinfection practices used in the food industry.
Rafael Ferguson, Undergraduate student
I was born and raised in Los Angeles, so the California drought (2011-17) had a lasting impact upon much of my adolescent and high school years. Consequently, I know I wanted to learn more about the intricacies of the water transport cycle and its effects on public well-being. These factors, along with general appreciation of the pursuit of knowledge through the sciences, let me to pursue B.E.S. in Environmental Engineering at JHU. I have been particularly interested in analyzing wastewater transformation products, as recharging California’s underground water beds with recycled water is an emerging solution to drought prevention.
Marcos Pascual, Undergraduate student
Previous lab member:
- Sara Nason (Postdoc): current position: research scientist at the Connecticut Agricultural Research Station